Product Description

Pharmacology

Methohexital binds to a distinct site which is associated with Cl− ionophores at GABAA receptors. This increases the length of time which the Cl− ionopores are open, thus causing an inhibitory effect.

Metabolism of methohexital is primarily hepatic (ie. taking place in the liver), via demethylation and oxidation. Side-chain oxidation is the primary means of metabolism involved in the termination of the drug's biological activity.

Protein binding is approximately 73% for methohexital.

Indications

Methohexital is primarily used to induce anaesthesia, and is generally provided as a sodium salt (ie. methohexital sodium). It is only used in hospital or ambulatory care (ie. in an ambulance) settings, under strict supervision. It has been commonly used to induce deep sedation, "twilight sleep" or general anaesthesia for oral surgery and dentistry

How to use Methohexital:

Use Methohexital as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Methohexital is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Methohexital at home, carefully follow the injection procedures taught to you by your health care provider.
If Methohexital contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
It is best to use Methohexital on an empty stomach.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of Methohexital, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Methohexital.

Important safety information:
Methohexital may cause drowsiness for up to 12 hours. Do not drive, operate machinery, or do anything else that could be dangerous for at least 12 hours following surgery.
Methohexital may cause seizures in patients with a history of seizures, especially partial seizure disorders.
If pain, whitening, or discoloration occurs at the injection site, tell your health care provider immediately.
Use Methohexital with caution in the ELDERLY because they may be more sensitive to its effects.
Use Methohexital with caution in CHILDREN younger than 1 month of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant while using Methohexital, discuss with your doctor the benefits and risks of using Methohexital during pregnancy. If you are or will be breast-feeding while you are using Methohexital, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Methohexital:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; coughing; drowsiness; flushing; headache; hiccups; itching; muscle twitching; nausea; pain at the injection site; restlessness; salivation; stomach pain; swelling of the veins; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning or swelling at the injection site; delirium; fast heartbeat; interrupted breathing; seizures; throat spasms.